Concepedia

John B. Lees‐Shepard

JB

6

Publications

471

Citations

6

H-Index

2018

Active since

Affiliations

Regeneron (United States)(Current)

University of Connecticut

John B. Lees‐Shepard is an author at Regeneron (United States) specializing in cytoskeleton, cell biology, and cell signaling.

ORCID

Top concepts

Publications per year

2018–2024

6

Publications

6

Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva

John B. Lees‐Shepard, Masakazu Yamamoto, Arpita Biswas et al. · Nature Communications · 2018 · 237 citations · Full text

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

Senem Aykul, Richard A. Corpina, Erich J. Goebel et al. · eLife · 2020 · 78 citations · Full text

, , +17

Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

John B. Lees‐Shepard, Sarah-Anne E. Nicholas, Sean J. Stoessel et al. · eLife · 2018 · 73 citations · Full text

Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1

Senem Aykul, Lily Huang, Lili Wang et al. · Journal of Clinical Investigation · 2022 · 60 citations · Full text

, , +22

How Activin A Became a Therapeutic Target in Fibrodysplasia Ossificans Progressiva

Dushyanth Srinivasan, Martin Arostegui, Erich J. Goebel et al. · Biomolecules · 2024 · 13 citations · Full text

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