T.C.M. Seegar

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket

Brandon Zimmerman, Brendan Kelly, Brian J. McMillan et al. · Cell · 2016 · 289 citations · Full text

Full-length Human Tetraspanin, Crystal Structure, Proteinlipid Interaction +6

Tie1-Tie2 Interactions Mediate Functional Differences between Angiopoietin Ligands

T.C.M. Seegar, Becca Eller, Dorothea Tzvetkova‐Robev et al. · Molecular Cell · 2010 · 180 citations · Full text

Angiogenesis, Endothelial Dysfunction, Angiopoietin Ligands +2

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10

T.C.M. Seegar, Lauren Killingsworth, Nayanendu Saha et al. · Cell · 2017 · 163 citations · Full text

Protein Secretion, Cellular Enzymology, Biochemistry +6

Development of a covalent inhibitor of gut bacterial bile salt hydrolases

Arijit A. Adhikari, T.C.M. Seegar, Scott B. Ficarro et al. · Nature Chemical Biology · 2020 · 111 citations · Full text

Covalent Inhibitor, Bioorganic Chemistry, Biochemistry +5

Structural basis for angiopoietin-1–mediated signaling initiation

Xuehong Yu, T.C.M. Seegar, Annamarie C. Dalton et al. · Proceedings of the National Academy of Sciences · 2013 · 70 citations · Full text

Growth Factor Receptors, Transcriptional Regulation, Signal Transduction +15