Improved intratumoral nanoparticle extravasation and penetration by mild hyperthermia

Li Li, Timo L.M. ten Hagen, Michiel Bolkestein, +6

Journal of Controlled Release

NanoparticlesNanomedicineEngineeringNanomaterialsNano-drug Delivery +3

A Novel ¹¹¹In-Labeled Anti–Prostate-Specific Membrane Antigen Nanobody for Targeted SPECT/CT Imaging of Prostate Cancer

Kristell L.S. Chatalic, Joke Veldhoven-Zweistra, Michiel Bolkestein, +5

Journal of Nuclear Medicine

LGR5 marks targetable tumor-initiating cells in mouse liver cancer

Wanlu Cao, Meng Li, Jiaye Liu, +18

Nature Communications

Investigation of Factors Determining the Enhanced Permeability and Retention Effect in Subcutaneous Xenografts

Michiel Bolkestein, Erik de Blois, Stuart Koelewijn, +4

Journal of Nuclear Medicine

Tissue EngineeringNanotherapeuticsEngineeringBiomedical EngineeringTumor Biology +20

Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury

Wanlu Cao, Kan Chen, Michiel Bolkestein, +13

Gastroenterology

Developmental BiologyCell DivisionMedicineAdult Stem CellQuiescent Stem Cells +5

Modeling liver cancer and therapy responsiveness using organoids derived from primary mouse liver tumors

Wanlu Cao, Jiaye Liu, Ling Wang, +13

Carcinogenesis

Adult Stem CellCell CultureCell ProliferationOrganoid TechnologyTumor Biology +27

Investigation of Particle Accumulation, Chemosensitivity and Thermosensitivity for Effective Solid Tumor Therapy Using Thermosensitive Liposomes and Hyperthermia

Wouter J.M. Lokerse, Michiel Bolkestein, Timo L.M. ten Hagen, +4

Theranostics

Tissue inhibitor of metalloproteinase-3 (TIMP3) expression decreases during melanoma progression and inhibits melanoma cell migration

Asha Das, Michiel Bolkestein, Thom van der Klok, +10

European Journal of Cancer

Cancer ResearchMedicineMelanomaTissue InhibitorCancer Cell Biology +12

Chromothripsis in Human Breast Cancer

Michiel Bolkestein, John Wong, Verena Thewes, +15

Cancer Research

Comparing the therapeutic potential of thermosensitive liposomes and hyperthermia in two distinct subtypes of breast cancer

Wouter J.M. Lokerse, Michiel Bolkestein, Simone U. Dalm, +4

Journal of Controlled Release

Breast OncologyNanotherapeuticsExtracellular MicrovesiclesBreast CancerTumor Targeting +6