Liam S. Chase

Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions

Serena Omo‐Lamai, Marco E. Zamora, Manthan N. Patel et al. · Advanced Materials · 2024 · 101 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids

Manthan N. Patel, Sachchidanand Tiwari, Yufei Wang et al. · Nature Biotechnology · 2025 · 57 citations · Full text

Pharmacy, Pharmaceutical Biotechnology, Pharmaceutics +16

Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape

Serena Omo‐Lamai, Yufei Wang, Manthan N. Patel et al. · Nature Nanotechnology · 2025 · 55 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects

Serena Omo‐Lamai, Yufei Wang, Manthan N. Patel et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2024 · 50 citations · Full text

Life Sciences, Molecular Biology, Pharmaceutics +17

Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation

Michael Zaleski, Liam S. Chase, Elizabeth D. Hood et al. · Advanced Materials · 2024 · 43 citations · Full text

Pharmacy, Immunology, Pharmaceutics +17