21:I[432972,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/30036bedc5269936.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/cd5e572bc3e4eb92.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/d4ac9dcf27f6ff52.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 22:T553,The increasing usage of nanoparticles has caused their considerable release into the aquatic environment. Meanwhile, anthropogenic CO₂ emissions have caused a reduction of seawater pH. However, their combined effects on marine species have not been experimentally evaluated. This study estimated the physiological toxicity of nano-TiO₂ in the mussel Mytilus coruscus under high pCO₂ (2500-2600 μatm). We found that respiration rate (RR), food absorption efficiency (AE), clearance rate (CR), scope for growth (SFG) and O:N ratio were significantly reduced by nano-TiO₂, whereas faecal organic weight rate and ammonia excretion rate (ER) were increased under nano-TiO₂ conditions. High pCO₂ exerted lower effects on CR, RR, ER and O:N ratio than nano-TiO₂. Despite this, significant interactions of CO₂-induced pH change and nano-TiO₂ were found in RR, ER and O:N ratio. PCA showed close relationships among most test parameters, i.e., RR, CR, AE, SFG and O:N ratio. The normal physiological responses were strongly correlated to a positive SFG with normal pH and no/low nano-TiO₂ conditions. Our results indicate that physiological functions of M. coruscus are more severely impaired by the combination of nano-TiO₂ and high pCO₂.

#	Concept	H-Index	Publications	Citations
1	Engineering	1	1	88
2	Environmental Engineering	1	1	88
3	Physiology	1	1	88
4	Aquaculture	1	1	88
5	Marine Biology	1	1	88

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