LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

Jan J. Molenaar, Raquel Domingo-Fernandéz, Marli E. Ebus, +27

Nature Genetics

Cell RegulationImmunologyLin28b InducesTumor SuppressorMedicine +3

Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation

Annika Sprüssel, Johannes H. Schulte, Susanne N. Weber, +17

Leukemia

Terminal DifferentiationDevelopmental BiologyMedicineHematologyMyeloid Neoplasia +7

A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies

Kristina Althoff, Anneleen Beckers, Emma Bell, +14

Oncogene

MiR‐137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A

Kristina Althoff, Anneleen Beckers, Andrea Odersky, +11

International Journal of Cancer

Tumor BiologyMir‐137 FunctionsEpigenetic RegulationMedicineCancer Cell Biology +13

Using droplet digital PCR to analyze<i>MYCN</i>and<i>ALK</i>copy number in plasma from patients with neuroblastoma

Marco Lodrini, Annika Sprüssel, Kathy Astrahantseff, +7

Oncotarget

The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models

Kristian W. Pajtler, Natalie Sadowski, Sandra Ackermann, +16

Oncotarget

Preclinical Neuroblastoma ModelsCancer BiologyGliomaTumor BiologyNeuroblastoma Cell Lines +14

The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma

Kristian W. Pajtler, Christina Weingarten, Theresa Thor, +11

Acta Neuropathologica Communications

Multiplexed Quantification of Four Neuroblastoma DNA Targets in a Single Droplet Digital PCR Reaction

Constantin Peitz, Annika Sprüssel, Rasmus B. Linke, +12

Journal of Molecular Diagnostics

Circulating Cell-Free DNA Assessment in Biofluids from Children with Neuroblastoma Demonstrates Feasibility and Potential for Minimally Invasive Molecular Diagnostics

Marco Lodrini, Jasmin Wünschel, Theresa M. Thole-Kliesch, +14

Cancers

Precision Cut Cancer Tissue Slices in Anti-Cancer Drug Testing

Florian T. Unger, Susanne Bentz, Jana Krüger, +6

Journal of Molecular Pathophysiology

Chemoprevention StrategyDigital PathologyTumor BiologyOncologyCancer Detection +15