Eng‐Hui Chew

Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

Jun Lu, Eng‐Hui Chew, Arne Holmgren · Proceedings of the National Academy of Sciences · 2007 · 507 citations · Full text

Cancer Therapy, Reductive Stress, Redox Signaling +14

Inhibition of the Human Thioredoxin System

Cristina Carvalho, Eng‐Hui Chew, Seyed Isaac Hashemy et al. · Journal of Biological Chemistry · 2008 · 446 citations · Full text

Biochemistry, Mercury Chemistry, Medicine +13

Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention

Eng‐Hui Chew, Amrita A. Nagle, Yaochun Zhang et al. · Free Radical Biology and Medicine · 2009 · 151 citations

Cancer Therapy, Reductive Stress, Aldehyde Dehydrogenase +8

Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury

Yaochun Zhang, Fei-Fei Gan, Sandeep B. Shelar et al. · Food and Chemical Toxicology · 2013 · 125 citations

Inflammation, Flavonoid Constituent, Medicine +9

Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: Synthesis, evaluation and SAR

Chong Yew Lee, Eng‐Hui Chew, Mei‐Lin Go · European Journal of Medicinal Chemistry · 2010 · 99 citations

Reductive Stress, Aldo-keto Reductase, Aldehyde Dehydrogenase +9