R A Roth

Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.

F Liu, R A Roth · Proceedings of the National Academy of Sciences · 1995 · 171 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic parameters using the purified, secreted soluble protease expressed by a recombinant baculovirus.

Deborah A. Bravo, John Gleason, R I Sanchez et al. · Journal of Biological Chemistry · 1994 · 148 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells.

Y Ebina, Marc Edery, L Ellis et al. · Proceedings of the National Academy of Sciences · 1985 · 128 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.

R A Roth, Delanie J. Cassell, Kwok‐Yin Wong et al. · Proceedings of the National Academy of Sciences · 1982 · 122 citations · Full text

Pharmacy, Biochemistry, Endocrinology +15

The regulatory role of known tyrosine autophosphorylation sites of the insulin receptor kinase domain. An assessment by replacement with neutral and negatively charged amino acids.

Bing Zhang, JM Tavaré, L Ellis et al. · Journal of Biological Chemistry · 1991 · 112 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16