Use of Human In Vitro Skin Models for Accurate and Ethical Risk Assessment: Metabolic Considerations

Nicola J. Hewitt, Robert J. Edwards, Ellen Fritsche, +13

Toxicological Sciences

DermatologyOxidative StressBioanalysisNative Human SkinMetabolic Engineering +17

Under the skin: Biotransformation of para-aminophenol and para-phenylenediamine in reconstructed human epidermis and human hepatocytes

Gerhard J. Nohynek, Daniel Duché, Alexia Garrigues, +3

Toxicology Letters

Tissue EngineeringReconstructed Human EpidermisBiochemistryCutaneous BiologyHuman Hepatocytes +3

Expression profiles of phases 1 and 2 metabolizing enzymes in human skin and the reconstructed skin models Episkin™ and full thickness model from Episkin™

Van Luu‐The, Daniel Duché, Corinne Ferraris, +3

The Journal of Steroid Biochemistry and Molecular Biology

Skin DevelopmentExpression ProfilesPhases 1BiochemistryMedicine +6

Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthic

Joan Eilstein, Guillaume Léreaux, Natali Budimir, +3

Archives of Toxicology

EngineeringBiochemistryCutaneous BiologyBioanalysisBiotechnology +8

Synthesis and Reactivity Toward Nucleophilic Amino Acids of 2,5-[¹³C]-Dimethyl-<i>p</i>-benzoquinonediimine

Joan Eilstein, Elena Giménez‐Arnau, Daniel Duché, +2

Chemical Research in Toxicology

TRP-2 specifically decreases WM35 cell sensitivity to oxidative stress

Quentin Michard, S Commo, Jean-Philippe Belaïdi, +7

Free Radical Biology and Medicine

Redox SignalingMolecular PhysiologyBiochemistryNatural SciencesRedox Biology +7

Mechanistic Studies on the Lysine-Induced<i>N</i>-Formylation of 2,5-Dimethyl-<i>p</i>-benzoquinonediimine

Joan Eilstein, Elena Giménez‐Arnau, Daniel Duché, +2

Chemical Research in Toxicology

Steroid metabolism and profile of steroidogenic gene expression in Episkin™: High similarity with human epidermis

Van Luu‐The, Corinne Ferraris, Daniel Duché, +3

The Journal of Steroid Biochemistry and Molecular Biology

Skin DevelopmentDevelopmental BiologyCutaneous BiologyHuman EpidermisEndocrinology +6

Sensitization to p-amino aromatic compounds: Study of the covalent binding of 2,5-dimethyl-p-benzoquinonediimine to a model peptide by electrospray ionization tandem mass spectrometry

Joan Eilstein, Elena Giménez‐Arnau, Daniel Duché, +4

Bioorganic & Medicinal Chemistry

Covalent BindingEngineeringModel PeptideBiochemistryMedicine +11

Use of read-across and computer-based predictive analysis for the safety assessment of PEG cocamines

Julie A. Skare, Karen Blackburn, Shengde Wu, +6

Regulatory Toxicology and Pharmacology