21:I[432972,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/2d7aa753e81324a8.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 22:T468,Phototherapy is considered a promising alternative to conventional tumor treatments due to its noninvasive modality and effective therapeutic effect. However, designing a photosensitizer with satisfactory therapeutic effect and high security remains a considerable challenge. Herein, a series of dimeric heptamethine cyanine photosensitizers with an aromatic diphenol linker at the meso position is developed to improve the photothermal conversion efficiency (PCE). Thanks to the extended conjugate system and high steric hindrance, the screened 26NA-NIR and 44BP-NIR exhibit high PCE (≈35%), bright near-infrared (NIR) fluorescence, excellent reactive oxygen species (ROS) generation capability, and improved photostability. Furthermore, their outstanding performance on imaging-guided PDT-PTT synergistic therapy is demonstrated by in vivo and in vitro experiments. In conclusion, this study designs a series of dimeric heptamethine cyanine photosensitizers and presents two compounds for potential clinical applications. The strategy provides a new method to design NIR photosensitizers for imaging-guided cancer treatment.23:T43a,The second near-infrared window (NIR-II, 900–1700 nm) fluorescence imaging has garnered considerable attention for its deep tissue penetration and high contrast. However, the development of small molecular fluorophores that encompass the NIR-II wavelength, high brightness, and large Stokes shift presents a formidable challenge. Herein, we report a series of phenanthridinium-based fluorophores, named YH dyes, which exhibit high brightness and large Stokes shift. Among these dyes, YH-1c demonstrates the best NIR-II fluorescence quantum yield (2.06% in DMSO) and excellent photostability. As a proof to concept, stunningly rich vascular details in mice were obtained through tail-vein injection of YH-1c NPs, where even under 5-fold magnification, clear visualization of deep abdominal microvessel details down to a diameter of ca. 10 μm was achieved, with a signal-to-background ratio reaching 5.21. This study not only provides a promising tool for high spatiotemporal resolution imaging but also imparts valuable insights for the design of novel NIR-II molecular scaffolds.24:T4b0,In vivo selective fluorescence imaging of carboxylesterase 2 (CES2) remains a great challenge because existing fluorescence probes can potentially suffer from interference by other hydrolases. In addition, some fluorescent probes that have been separately reported for measuring CES2 activity in vitro are affected by autofluorescence and absorption of the biological matrix due to their limited emission wavelength or short Stokes shift. Herein, based on the substrate preference and catalytic performance of CES2, a novel and NIR fluorescent probe was developed, in which a hemi-cyanine dye ester derivative was used as the basic fluorescent group. In the presence of CES2, the probe was hydrolyzed to expose the fluorophore CZX-OH (λ_abs ∼ 675 nm, λ_em ∼ 850 nm), which led to a notable red-shift in the fluorescence (∼175 nm) spectrum. Confocal imaging of cells and live mice demonstrated that the fluorescent signal of this probe was related to the real activities of CES2 in cancer cells. All these results will powerfully promote the screening of CES2 regulators and the analysis of CES2-related physiological and pathological processes.

#	Concept	H-Index	Publications	Citations
1	Engineering	3	3	70
2	Medicine	2	2	53
3	Biomedical Engineering	2	2	53
4	Health Sciences	1	1	18
5	Natural Sciences	1	1	18

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