Zhenyu Cai

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

Jie Zhao, Siriporn Jitkaew, Zhenyu Cai et al. · Proceedings of the National Academy of Sciences · 2012 · 906 citations · Full text

Life Sciences, Cell Biology, Pathobiology +14

Neuronal extracellular vesicle derived miR-98 prevents salvageable neurons from microglial phagocytosis in acute ischemic stroke

Jin Yang, Lulu Cao, Xipeng Wang et al. · Cell Death and Disease · 2021 · 70 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

High glucose downregulates the effects of autophagy on osteoclastogenesis via the AMPK/mTOR/ULK1 pathway

Zhenyu Cai, Bo Yang, Yingxu Shi et al. · Biochemical and Biophysical Research Communications · 2018 · 69 citations

Life Sciences, Biochemistry, Cell Biology +14

Identification of the Raf kinase inhibitor TAK‐632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3

Xiaofei Chen, Chunlin Zhuang, Yibin Ren et al. · British Journal of Pharmacology · 2019 · 57 citations · Full text

Medicine, Cell Biology, Pharmacology +12

<i>N</i>-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[<i>d</i>]thiazol-2-yl)cyclopropanecarboxamide (TAK-632) Analogues as Novel Necroptosis Inhibitors by Targeting Receptor-Interacting Protein Kinase 3 (RIPK3): Synthesis, Structure–Activity Relationships, and in Vivo Efficacy

Hao Zhang, Lijuan Xu, Xia Qin et al. · Journal of Medicinal Chemistry · 2019 · 53 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17