The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells <i>In vitro</i> and <i>In vivo</i>

Hiroshi Ikeda, Teru Hideshima, Mariateresa Fulciniti, +18

Clinical Cancer Research

Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)

Tobias Welte, R. Phillip Dellinger, Henning Ebelt, +39

Intensive Care Medicine

Targeted induction of apoptosis by chimeric granzyme B fusion proteins carrying antibody and growth factor domains for cell recognition

Benjamin Dälken, Ulrike Giesübel, Shirley K. Knauer, +1

Cell Death and Differentiation

Growth FactorCell RecognitionApoptosisImmunologyCell Death +8

A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway

Bianca Helling, Martin König, Benjamin Dälken, +15

Immunology and Cell Biology

Efficacy, safety, and palatability of arpraziquantel (L-praziquantel) orodispersible tablets in children aged 3 months to 6 years infected with Schistosoma in Côte d'Ivoire and Kenya: an open-label, partly randomised, phase 3 trial

Eliézer K. N’Goran, Maurice R. Odiere, Ronald Assandé Aka, +14

The Lancet Infectious Diseases

MalariaCôte D'ivoirePediatricsSchistosomiasisOrodispersible Tablets +3

Induction of programmed cell death in ErbB2/HER2-expressing cancer cells by targeted delivery of apoptosis-inducing factor

Hayat Mahmud, Benjamin Dälken, Winfried S. Wels

Molecular Cancer Therapeutics

Cell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast<i>Pichia pastoris</i>

Ulrike Giesübel, Benjamin Dälken, Hayat Mahmud, +1

Biochemical Journal

Fungal Cell BiologyApoptosisImmunologyHuman GrbCell Death +16

Maltose-Binding Protein Enhances Secretion of Recombinant Human Granzyme B Accompanied by In Vivo Processing of a Precursor MBP Fusion Protein

Benjamin Dälken, Robert A. Jabulowsky, Pranav Oberoi, +2

PLoS ONE

Surface Charge-Modification Prevents Sequestration and Enhances Tumor-Cell Specificity of a Recombinant Granzyme B–TGFα Fusion Protein

Robert A. Jabulowsky, Pranav Oberoi, Hayat Bähr-Mahmud, +2

Bioconjugate Chemistry

ImmunotherapeuticsCancer BiologyTumor BiologyTumor ImmunityCancer Cell Biology +14

Efficacy and safety of tregalizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase IIb, randomised, placebo-controlled trial

Ronald van Vollenhoven, Edward Keystone, Vibeke Strand, +13

Annals of the Rheumatic Diseases