Siân C. Piper

Lysine‐63‐linked ubiquitination is required for endolysosomal degradation of class I molecules

Lidia M. Duncan, Siân C. Piper, Roger B. Dodd et al. · The EMBO Journal · 2006 · 271 citations · Full text

Degradation of Endocytosed Epidermal Growth Factor and Virally Ubiquitinated Major Histocompatibility Complex Class I Is Independent of Mammalian ESCRTII

Katherine Bowers, Siân C. Piper, Melissa A. Edeling et al. · Journal of Biological Chemistry · 2005 · 187 citations · Full text

Immunology, Molecular Biology, Cytoskeleton +20

A Presenilin 1 Mutation Associated with Familial Frontotemporal Dementia Inhibits γ-Secretase Cleavage of APP and Notch

Zareen Amtul, Patrick A. Lewis, Siân C. Piper et al. · Neurobiology of Disease · 2002 · 89 citations · Full text

Neurodegenerative Diseases, Genetic Disorder, Dementia +10

A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I

Michael Parkinson, Siân C. Piper, Nicholas A. Bright et al. · Biochemical Journal · 2015 · 56 citations · Full text

Escrt-iii Protein, Signal Transduction, Non-canonical Escrt Pathway +15

Expression of BRI–amyloid β peptide fusion proteins: a novel method for specific high-level expression of amyloid β peptides

Patrick A. Lewis, Siân C. Piper, Matthew Baker et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2001 · 42 citations

Protein Expression, Biochemistry, Protein Folding +10