David Lagares

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Fei Liu, David Lagares, Kyoung Moo Choi et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2014 · 814 citations

Life Sciences, Genetics, Gene Expression +11

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

Yue Zhang, Faezeh Vasheghani, Yinghua Li et al. · Annals of the Rheumatic Diseases · 2014 · 414 citations

Life Sciences, Cell Biology, Molecular Medicine +17

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

David Lagares, Alba Santos, Paula Grasberger et al. · Science Translational Medicine · 2017 · 232 citations · Full text

Life Sciences, Cell Biology, Pathology +17

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

Faezeh Vasheghani, Yue Zhang, Yinghua Li et al. · Annals of the Rheumatic Diseases · 2015 · 219 citations · Full text

Medicine, Orthopaedic Surgery, Orthopedic Surgery +17

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

Andrew J. Haak, Enis Kostallari, Delphine Sicard et al. · Science Translational Medicine · 2019 · 218 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17