Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Fei Liu, David Lagares, Kyoung Moo Choi, +13

American Journal of Physiology-Lung Cellular and Molecular Physiology

Molecular RegulationHealthy Lung TissueMechanotransductionBiomedical EngineeringCellular Physiology +28

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

Yue Zhang, Faezeh Vasheghani, Yinghua Li, +9

Annals of the Rheumatic Diseases

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

David Lagares, Alba Santos, Paula Grasberger, +14

Science Translational Medicine

PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

Faezeh Vasheghani, Yue Zhang, Yinghua Li, +15

Annals of the Rheumatic Diseases

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

Andrew J. Haak, Enis Kostallari, Delphine Sicard, +22

Science Translational Medicine

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

David Lagares, Óscar Busnadiego, Rosa A. García‐Fernández, +12

Arthritis & Rheumatism

ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis

David Lagares, Parisa Ghassemi-Kakroodi, Caroline Tremblay, +22

Nature Medicine

InflammationFibrosisOrgan FibrosisImmunologyMedicine +3

Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Endothelin-1 Expression by a Novel, Redox-Sensitive Mechanism Involving mRNA Stability

Fernando Rodrı́guez-Pascual, Mariano Redondo‐Horcajo, Noemi Magán-Marchal, +4

Molecular and Cellular Biology

Molecular RegulationRedox BiologyCellular PhysiologyOxidative StressTranscriptional Regulation +19

The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis

Rachel S. Knipe, Clemens K. Probst, David Lagares, +11

American Journal of Respiratory Cell and Molecular Biology

Acute Lung InjuryInflammatory Lung DiseaseAdvanced Lung DiseaseLung InflammationBiomedical Research +20

LOXL4 Is Induced by Transforming Growth Factor β1 through Smad and JunB/Fra2 and Contributes to Vascular Matrix Remodeling

Óscar Busnadiego, José González, David Lagares, +4

Molecular and Cellular Biology

Cell ProliferationGrowth Factor β1Cellular PhysiologyTranscriptional RegulationSignaling Pathway +16