Steven J. Orcutt

Binding of Substrate in Two Conformations to Human Prothrombinase Drives Consecutive Cleavage at Two Sites in Prothrombin

Steven J. Orcutt, Sriram Krishnaswamy · Journal of Biological Chemistry · 2004 · 65 citations · Full text

Protein Assembly, Proteasome, Molecular Biology +16

Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase

Elsa P. Bianchini, Steven J. Orcutt, Peter Panizzi et al. · Proceedings of the National Academy of Sciences · 2005 · 60 citations · Full text

Extended Interactions with Prothrombinase Enforce Affinity and Specificity for Its Macromolecular Substrate

Steven J. Orcutt, Concetta Pietropaolo, Sriram Krishnaswamy · Journal of Biological Chemistry · 2002 · 40 citations · Full text

Membrane Binding by Prothrombin Mediates Its Constrained Presentation to Prothrombinase for Cleavage

Harlan N. Bradford, Steven J. Orcutt, Sriram Krishnaswamy · Journal of Biological Chemistry · 2013 · 31 citations · Full text

Proteinlipid Interaction, Protein Secretion, Protein Function +10

Neutralization of Plasminogen Activator Inhibitor I (PAI-1) by the Synthetic Antagonist PAI-749 via a Dual Mechanism of Action

Stephen J. Gardell, Julie A. Krueger, Thomas A Antrilli et al. · Molecular Pharmacology · 2007 · 28 citations