Concepedia
4
Publications
152
Citations
H-Index
2016
Active since
Affiliations
Aalborg University(Current)
University of British Columbia
Christian Holt is an author at Aalborg University.
Publications per year
2016–2020
Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel
Kaiqian Wang, Christian Holt, Jocelyn Lu et al. · Proceedings of the National Academy of Sciences · 2018 · 53 citations · Full text
The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor
Mads T. Søndergaard, Yingjie Liu, K.T. Larsen et al. · Journal of Biological Chemistry · 2016 · 38 citations · Full text
Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca<sup>2+</sup> binding and cause misfolding
Kaiqian Wang, Malene Brohus, Christian Holt et al. · The Journal of Physiology · 2020 · 35 citations · Full text
The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor
Christian Holt, Louise Hamborg, Kelvin Lau et al. · Journal of Biological Chemistry · 2020 · 26 citations · Full text
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