High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling

De Xie, Hairong Zhao, Jiaming Lu, +8

American Journal of Physiology-Endocrinology and Metabolism

High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2‐Mediated Autophagy Dysfunction and Ferroptosis

Wei Yu, Weidong Liu, De Xie, +9

Oxidative Medicine and Cellular Longevity

Activation of p62-NRF2 Axis Protects against Doxorubicin-Induced Ferroptosis in Cardiomyocytes: A Novel Role and Molecular Mechanism of Resveratrol

Wei Yu, Chunjuan Chen, Chenxi Xu, +10

The American Journal of Chinese Medicine

Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages

Wei Yu, Chunjuan Chen, Wanling Zhuang, +12

Free Radical Biology and Medicine

InflammationMetabolic SyndromeInsulin SignalingSignal TransductionMolecular Physiology +11

Uric acid inhibits HMGB1-TLR4-NF-κB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia

Qiang Wang, Hairong Zhao, Yuan Gao, +9

Biochemical and Biophysical Research Communications

NeuroinflammationInflammationRedox SignalingOxygen-glucose Deprivation/reoxygenation InjuryMedicine +11

High uric acid promotes dysfunction in pancreatic β cells by blocking IRS2/AKT signalling

Yaqiu Hu, Hairong Zhao, Jiaming Lu, +8

Molecular and Cellular Endocrinology

Signal TransductionMolecular PhysiologyPancreatic CancerPhysiologyDiabetes +6

Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation

Hairong Zhao, Jiaming Lu, Furong He, +15

Frontiers in Immunology

Vespakinin-M, a natural peptide from Vespa magnifica, promotes functional recovery in stroke mice

Hairong Zhao, Mei Wang, Yuan Gao, +13

Communications Biology

Mastoparan M Suppressed NLRP3 Inflammasome Activation by Inhibiting MAPK/NF-κB and Oxidative Stress in Gouty Arthritis

Yunbo Yan, Linqian Yu, Binyang Chen, +7

Journal of Inflammation Research

Autophagy protects against high uric acid-induced hepatic insulin resistance

Furong He, Mei Wang, Hairong Zhao, +10

Molecular and Cellular Endocrinology

Metabolic SyndromeMitophagyCell AutophagyLiver PhysiologyDiabetes +6