RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome

Natasha L. Pacheco, Michael R. Heaven, Leanne M. Holt, +5

Molecular Autism

Hemoglobin oxidation–dependent reactions promote interactions with band 3 and oxidative changes in sickle cell–derived microparticles

Sirsendu Jana, Michael Brad Strader, Fantao Meng, +9

JCI Insight

Iron MetabolismCell DeathRedox BiologyOxidative ChangesOxidative Stress +17

Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease

Michael R. Heaven, Daniel Flint, Shan M. Randall, +6

Journal of Proteome Research

ImmunologyMolecular BiologyPathologyNeurochemical BiomarkersExperimental Neuropathology +21

Post-translational modification as a response to cellular stress induced by hemoglobin oxidation in sickle cell disease

Michael Brad Strader, Sirsendu Jana, Fantao Meng, +4

Scientific Reports

Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model

Zenaide Quezado, Sayuri Kamimura, Meghann L. Smith, +19

Blood Cells Molecules and Diseases

MitophagyMitochondrial FunctionBiochemistryScd Mouse ModelLipid Peroxidation +9

Systematic evaluation of data‐independent acquisition for sensitive and reproducible proteomics—a prototype design for a single injection assay

Michael R. Heaven, Adam J. Funk, Archie L. Cobbs, +4

Journal of Mass Spectrometry

Micro-Data-Independent Acquisition for High-Throughput Proteomics and Sensitive Peptide Mass Spectrum Identification

Michael R. Heaven, Archie L. Cobbs, Y.-w. Nei, +5

Analytical Chemistry

Biological Mass SpectrometryMolecular BiologyProtein AnalysisMicro-data-independent AcquisitionPeptide Science +23

HIF-1α-Dependent Metabolic Reprogramming, Oxidative Stress, and Bioenergetic Dysfunction in SARS-CoV-2-Infected Hamsters

Sirsendu Jana, Michael R. Heaven, Charles B. Stauft, +4

International Journal of Molecular Sciences

Acute Lung InjuryHif-1α-dependent Metabolic ReprogrammingInflammatory Lung DiseaseLung InflammationImmunology +23

Cell-Free Hemoglobin Does Not Attenuate the Effects of SARS-CoV-2 Spike Protein S1 Subunit in Pulmonary Endothelial Cells

Sirsendu Jana, Michael R. Heaven, Abdu I. Alayash

International Journal of Molecular Sciences

Acute Lung InjuryInflammatory Lung DiseasePyrimidine MetabolismLung InflammationImmunology +23

Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis

Michael R. Heaven, Anthony W. Herren, Daniel Flint, +7

Molecular & Cellular Proteomics