Increasing the Efficiency of CRISPR/Cas9-mediated Precise Genome Editing of HSV-1 Virus in Human Cells

Chaolong Lin, Huanhuan Li, Mengru Hao, +6

Scientific Reports

Oncolytic virus expressing PD-1 inhibitors activates a collaborative intratumoral immune response to control tumor and synergizes with CTLA-4 or TIM-3 blockade

Fei Ju, Yong Luo, Chaolong Lin, +19

Journal for ImmunoTherapy of Cancer

Identified Hpd-1scfvBackground Oncolytic VirusesImmunologyPd-1 InhibitorsImmunoediting +16

Intratumoral Delivery of a PD-1–Blocking scFv Encoded in Oncolytic HSV-1 Promotes Antitumor Immunity and Synergizes with TIGIT Blockade

Chaolong Lin, Wenfeng Ren, Yong Luo, +11

Cancer Immunology Research

Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1

Zilong Xu, Yating Chang, Fei Ju, +14

Nature Communications

Intravenous Injections of a Rationally Selected Oncolytic Herpes Virus as a Potent Virotherapy for Hepatocellular Carcinoma

Yong Luo, Chaolong Lin, Wenfeng Ren, +9

Molecular Therapy — Oncolytics

VaccinationHepatologyImmunologyAntiviral TherapyVirology +5

Tumor-targeting oncolytic virus elicits potent immunotherapeutic vaccine responses to tumor antigens

Yong Luo, Chaolong Lin, Yidi Zou, +13

OncoImmunology

Development of an HSV-1 neutralization test with a glycoprotein D specific antibody for measurement of neutralizing antibody titer in human sera

Yong Luo, Dan Xiong, Huanhuan Li, +7

Virology Journal

A novel approach for rapid high-throughput selection of recombinant functional rat monoclonal antibodies

Qin Chen, Sheng-Ping Qiu, Huanhuan Li, +7

BMC Immunology

A potent neutralizing and protective antibody against a conserved continuous epitope on HSV glycoprotein D

Rui Tian, Fei Ju, Mengqin Yu, +12

Antiviral Research

VaccinationVaccine TargetImmunologyConserved Continuous EpitopeAntiviral Response +9