Pablo Morentin-Gutierrez

4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

Ian Churcher, Dirk Beher, Jonathan D. Best et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 80 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

Quantitation of Endogenous Metabolites in Mouse Tumors Using Mass-Spectrometry Imaging

John G. Swales, Alex Dexter, Grégory Hamm et al. · Analytical Chemistry · 2018 · 76 citations

Life Sciences, Biochemistry, Cancer Biology +17

In Vivo Characterization of Aβ(40) Changes in Brain and Cerebrospinal Fluid Using the Novel γ-Secretase Inhibitor N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) in the Rat

Jonathan D. Best, Mark T. Jay, Franklin Otu et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 64 citations

Life Sciences, Neuroscience, Pharmacology +17

Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy

William McCoull, Andrew Bailey, Peter Barton et al. · Journal of Medicinal Chemistry · 2017 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8