Coxsackievirus B1 Is Associated With Induction of β-Cell Autoimmunity That Portends Type 1 Diabetes

Olli H. Laitinen, Hanna Honkanen, Outi Pakkanen, +16

Diabetes

ImmunodeficienciesViral PathogenesisImmunologyPathologyImmune Regulation +16

Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity

Hanna Honkanen, Sami Oikarinen, Noora Nurminen, +14

Diabetologia

Diagnostic VirologySeveral MonthsViral PersistenceAutoimmune DiseaseViral Diagnostics +9

Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes

Amir‐Babak Sioofy‐Khojine, Jussi Lehtonen, Noora Nurminen, +12

Diabetologia

Insulin-driven AutoimmunityViral PersistenceAutoimmune DiseasePathogenesisImmunology +9

A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates

Virginia M. Stone, Minna M. Hankaniemi, Olli H. Laitinen, +9

Science Advances

A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes

Virginia M. Stone, Minna M. Hankaniemi, Emma Svedin, +6

Diabetologia

Optimized production and purification of Coxsackievirus B1 vaccine and its preclinical evaluation in a mouse model

Minna M. Hankaniemi, Olli H. Laitinen, Virginia M. Stone, +7

Vaccine

VaccinationMolecular VirologyVaccine DevelopmentSynthetic VirologyImmunology +9

Coxsackievirus B Vaccines Prevent Infection-Accelerated Diabetes in NOD Mice and Have No Disease-Inducing Effect

Virginia M. Stone, Marta Butrym, Minna M. Hankaniemi, +4

Diabetes

SpyTag/SpyCatcher display of influenza M2e peptide on norovirus-like particle provides stronger immunization than direct genetic fusion

Vili Lampinen, Stina Gröhn, Saana Soppela, +3

Frontiers in Cellular and Infection Microbiology

Modular vaccine platform based on the norovirus-like particle

Vili Lampinen, Suvi Heinimäki, Olli H. Laitinen, +4

Journal of Nanobiotechnology

Combination of three virus-derived nanoparticles as a vaccine against enteric pathogens; enterovirus, norovirus and rotavirus

Suvi Heinimäki, Minna M. Hankaniemi, Amir‐Babak Sioofy‐Khojine, +5

Vaccine