An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells

Antonio Filareto, Sarah Parker, Radbod Darabi, +9

Nature Communications

Regenerative MedicineTissue EngineeringGene TherapiesCell TherapyEngineering +11

Discovery of Enzyme Modulators via High-Throughput Time-Resolved FRET in Living Cells

Simon Gruber, Rǎzvan L. Cornea, Ji Li, +7

SLAS DISCOVERY

High-Throughput Spectral and Lifetime-Based FRET Screening in Living Cells to Identify Small-Molecule Effectors of SERCA

Tory Schaaf, Kurt C. Peterson, Benjamin D. Grant, +6

SLAS DISCOVERY

BiochemistryBiomolecular ToolNatural SciencesLifetime-based Fret ScreeningFret Hits +13

An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors

Chih Hung Lo, Nagamani Vunnam, Andrew K. Lewis, +7

SLAS DISCOVERY

Noncompetitive inhibitors of TNFR1 probe conformational activation states

Chih Hung Lo, Tory Schaaf, Benjamin D. Grant, +5

Science Signaling

Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells

Daniel R. Stroik, Samantha L. Yuen, Kevyn A. Janicek, +6

Scientific Reports

Red-Shifted FRET Biosensors for High-Throughput Fluorescence Lifetime Screening

Tory Schaaf, Ang Li, Benjamin D. Grant, +7

Biosensors

Photonic SensorRed-shifted Fret BiosensorsEngineeringBiosensing SystemsBiomedical Diagnostics +10

Spectral Unmixing Plate Reader: High-Throughput, High-Precision FRET Assays in Living Cells

Tory Schaaf, Kurt C. Peterson, Benjamin D. Grant, +2

SLAS DISCOVERY

EngineeringBiomolecular ToolMolecular BiologyMicroplate ReaderRfp Emission +14

Live-Cell Cardiac-Specific High-Throughput Screening Platform for Drug-Like Molecules That Enhance Ca2+ Transport

Tory Schaaf, Evan Kleinboehl, Samantha L. Yuen, +5

Cells

Cardiac MuscleProteinlipid InteractionHeart FailureBiomolecular ToolEnhance Ca2+ Transport +20

Fluorescence-Based TNFR1 Biosensor for Monitoring Receptor Structural and Conformational Dynamics and Discovery of Small Molecule Modulators

Chih Hung Lo, Tory Schaaf, David D. Thomas, +1

Methods in molecular biology

Conformational DynamicsBiosensing SystemsNatural SciencesMolecular BiologyMonitoring Receptor Structural +7