Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

Lu Xu, Yang Zhang, Kang Tian, +13

Journal of Experimental & Clinical Cancer Research

SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer

Yuesheng Lv, Wenjing Zhang, Jinyao Zhao, +13

Signal Transduction and Targeted Therapy

Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer

Jinrui Zhang, Qiong Li, Yueguang Wu, +14

Cell Communication and Signaling

Neratinib induces ErbB2 ubiquitylation and endocytic degradation via HSP90 dissociation in breast cancer cells

Yingqiu Zhang, Jinrui Zhang, Congcong Liu, +11

Cancer Letters

Tumor BiologyEndocytic DegradationCell RegulationMedicineBreast Cancer Cells +8

The USP7 Inhibitor P5091 Induces Cell Death in Ovarian Cancers with Different P53 Status

Mengying Wang, Yayun Zhang, Taishu Wang, +12

Cellular Physiology and Biochemistry

USP42 drives nuclear speckle mRNA splicing via directing dynamic phase separation to promote tumorigenesis

Shuyan Liu, Taishu Wang, Yulin Shi, +12

Cell Death and Differentiation

The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer

Jinrui Zhang, Shuyan Liu, Qiong Li, +13

Cell Death and Differentiation

USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress

Yueguang Wu, Yingqiu Zhang, Duchuang Wang, +16

Cell Death and Disease

Lung AdenocarcinomaUsp29 ExpressionCancer BiologyTumor BiologyOxidative Stress +15

The exon 19-deleted EGFR undergoes ubiquitylation-mediated endocytic degradation via dynamin activity-dependent and -independent mechanisms

Taishu Wang, Jinrui Zhang, Shanshan Wang, +14

Cell Communication and Signaling

The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma

Shanshan Wang, Taishu Wang, Shaoxuan Cheng, +11

Cell Death and Differentiation

Tumor BiologyUrologyGenitourinary CancerMedicineEnzyme Usp35 +5