Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice

Naoto Nagata, Liang Xu, Susumu Kohno, +11

Diabetes

Fat BrowningAdipose Tissue BrowningGlucoraphanin Ameliorates ObesityMetabolic DisorderGlucose Tolerance +16

Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

Tatsunori Nishimura, Asuka Nakata, Xiaoxi Chen, +16

Oncogene

Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

Fengkai Li, Shunsuke Kitajima, Susumu Kohno, +15

Cancer Research

The RB–IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity

Shunsuke Kitajima, Akiyo Yoshida, Susumu Kohno, +21

Oncogene

InflammationEndocrine Therapy ResistanceMitochondrial FunctionRb–il-6 AxisMitochondrial Dynamic +7

Methyl galbanate, a novel inhibitor of nitric oxide production in mouse macrophage RAW264.7 cells

Susumu Kohno, Tomiyasu Murata, Ayumi Sugiura, +4

Journal of Natural Medicines

Macrophage BiologyInflammationNitric Oxide ProductionNovel InhibitorMethyl Galbanate +13

ATM mediates pRBfunction to control DNMT1 protein stability and DNA methylation

Awad Shamma, Misa Suzuki, Naoyuki Hayashi, +10

Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University)

Treatment of Retinoblastoma 1–Intact Hepatocellular Carcinoma With Cyclin‐Dependent Kinase 4/6 Inhibitor Combination Therapy

Jindan Sheng, Susumu Kohno, Nobuhiro Okada, +15

Hepatology

Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line

Masafumi Noguchi, Susumu Kohno, Anna Pellattiero, +9

Cell Death and Disease

Mitochondrial FunctionMitochondrial DynamicMedicinePharmacologyCombo Gefitinib-myls22 Treatment +11

A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling

Hayato Muranaka, Akemi Hayashi, K Minami, +12

Oncogenesis

Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance

Ahmed M. Hegazy, Daisuke Yamada, Masahiko Kobayashi, +10

Journal of Biological Chemistry