Lee-Ya Chu

RNA recognition motifs of disease-linked RNA-binding proteins contribute to amyloid formation

Sashank Agrawal, Pan-Hsien Kuo, Lee-Ya Chu et al. · Scientific Reports · 2019 · 53 citations · Full text

Structural insights into RNA unwinding and degradation by RNase R

Lee-Ya Chu, Tung-Ju Hsieh, Bagher Golzarroshan et al. · Nucleic Acids Research · 2017 · 46 citations · Full text

Crystal Structure, Systems Biology, Protein Folding +13

Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1

Kuan-Wei Huang, Tung-Chang Liu, Ruei-Yue Liang et al. · PLoS Biology · 2018 · 42 citations · Full text

Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES)

Kuan-Wei Huang, Kai‐Cheng Hsu, Lee-Ya Chu et al. · Journal of Medicinal Chemistry · 2016 · 27 citations

Combinatorial Chemistry, Crystal Structure, Viral Replication +21

Crystal structure of dimeric human PNPase reveals why disease-linked mutants suffer from low RNA import and degradation activities

Bagher Golzarroshan, Chia‐Liang Lin, Chia‐Lung Li et al. · Nucleic Acids Research · 2018 · 27 citations · Full text

Crystal Structure, Engineering, Structural Bioinformatics +16