Tarra Fuchs

3-Amino-1,2,4-benzotriazine 4-Oxide:  Characterization of a New Metabolite Arising from Bioreductive Processing of the Antitumor Agent 3-Amino-1,2,4-benzotriazine 1,4-Dioxide (Tirapazamine)

Tarra Fuchs, Goutam Chowdhury, Charles L. Barnes et al. · The Journal of Organic Chemistry · 2000 · 68 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Reaction of the Hypoxia-Selective Antitumor Agent Tirapazamine with a C1‘-Radical in Single-Stranded and Double-Stranded DNA:  The Drug and Its Metabolites Can Serve as Surrogates for Molecular Oxygen in Radical-Mediated DNA Damage Reactions

Jae-Taeg Hwang, Marc M. Greenberg, Tarra Fuchs et al. · Biochemistry · 1999 · 62 citations

Medicine, Oncology, Pharmacology +14

A mass spectrometry study of tirapazamine and its metabolites: Insights into the mechanism of metabolic transformations and the characterization of reaction intermediates

Dmitri V. Zagorevskii, Minghu Song, Curt M. Breneman et al. · Journal of the American Society for Mass Spectrometry · 2003 · 38 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Effects of Amino Acid Chirality and the Chemical Linker on the Cell Permeation Characteristics of Cyclic Prodrugs of Opioid Peptides

Bianca M. Liederer, Tarra Fuchs, David Vander Velde et al. · Journal of Medicinal Chemistry · 2006 · 18 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17