The human gut bacterial genotoxin colibactin alkylates DNA

Matthew R. Wilson, Yindi Jiang, Peter W. Villalta, +11

Science

Reactivity of an Unusual Amidase May Explain Colibactin’s DNA Cross-Linking Activity

Yindi Jiang, Alessia Stornetta, Peter W. Villalta, +5

Journal of the American Chemical Society

Host Cell DnaBiosynthesisBiochemistryNatural SciencesEnzyme Catalysis +9

DNA Adducts from Anticancer Drugs as Candidate Predictive Markers for Precision Medicine

Alessia Stornetta, Maike Zimmermann, George D. Cimino, +2

Chemical Research in Toxicology

Chemoprevention StrategyPathologyNucleic Acid BiomarkersBiomarker-driven Drug SelectionMedicinal Chemistry +16

Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS³ Adductomic Approach

Alessia Stornetta, Peter W. Villalta, Stephen S. Hecht, +2

Analytical Chemistry

A small molecule inhibitor prevents gut bacterial genotoxin production

Matthew R. Volpe, J. Velilla, Martin Daniel-Ivad, +8

Nature Chemical Biology

Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde

Amin Sobh, Alex Loguinov, Alessia Stornetta, +4

Toxicological Sciences

GeneticsAcetaldehyde ToleranceMolecular BiologyEpigeneticsTumor Biology +17

Extension of Diagnostic Fragmentation Filtering for Automated Discovery in DNA Adductomics

Kevin Murray, Erik S. Carlson, Alessia Stornetta, +3

Analytical Chemistry

DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A

Alessia Stornetta, Peter W. Villalta, Frederike Gossner, +3

Chemical Research in Toxicology

Aldo-keto ReductaseMetabolomic ProfilingPr104a-derived Dna AdductsCancer BiologyRedox Biology +21

In Vivo Identification of Adducts from the New Hypoxia-Activated Prodrug CP-506 Using DNA Adductomics

Morwena J. Solivio, Alessia Stornetta, Julie Gilissen, +5

Chemical Research in Toxicology

Coexposure to Inhaled Aldehydes or Carbon Dioxide Enhances the Carcinogenic Properties of the Tobacco-Specific Nitrosamine 4-Methylnitrosamino-1-(3-pyridyl)-1-butanone in the A/J Mouse Lung

Lisa A. Peterson, Marissa K. Oram, Monica Flavin, +12

Chemical Research in Toxicology

AsthmaCarbon DioxideNnk-induced Lung AdenomasInflammatory Lung DiseaseLung Inflammation +21