Dynamic DNA methylation programs persistent adverse effects of early-life stress

Chris Murgatroyd, Alexandre V. Patchev, Yonghe Wu, +6

Nature Neuroscience

ChromatinEarly Life ExposureStressGeneticsDna Methylation +7

Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis

Verena Körber, Jing Yang, Pankaj Barah, +22

Cancer Cell

Neuro-oncologyTumoral PathologyDevelopmental BiologyTumor HeterogeneityEvolutionary Trajectories +11

Early-Life Stress Reduces DNA Methylation of the Pomc Gene in Male Mice

Yonghe Wu, Alexandre V. Patchev, Guillaume Daniel, +2

Endocrinology

Epigenetic ChangeGeneticsDna MethylationReproductive BiologyEpigenetics +19

Genes learn from stress: How infantile trauma programs us for depression

Chris Murgatroyd, Yonghe Wu, Yvonne Bockmühl, +1

Epigenetics

Epigenetic ChangeDna MethylationMental HealthTrauma In ChildEpigenetics +20

GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile

Patricia M. Rusu, Chunxuan Shao, Anna Neuerburg, +21

Cell stem cell

GliomaMedicineCancer Cell BiologyDistinct Metabolic ProfileMetabolic Remodeling +6

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype

Yonghe Wu, Michael Fletcher, Zuguang Gu, +19

Nature Communications

Branched‐chain ketoacids secreted by glioblastoma cells via <scp>MCT</scp> 1 modulate macrophage phenotype

Lidia Santos Silva, Gernot Poschet, Yannic Nonnenmacher, +11

EMBO Reports

Branched‐chain KetoacidsMolecular PhysiologySignal TransductionGliomaModulate Macrophage Phenotype +11

The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer

Verena Thewes, Ronald Simon, Mario Hlevnjak, +22

Oncogene

Tumor BiologyErα-negative Breast CancerSustains GrowthBreast OncologyEndocrine-related Cancer +11

The Janus face of DNA methylation in aging

Chris Mugatroyd, Yonghe Wu, Yvonne Bockmühl, +1

Aging

Lifespan ExtensionChromatinAgingLongevityGenetics +13

Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy

Tianping Peng, Xiujian Ma, Wei Hua, +46

Cell stem cell