Applying ecological and evolutionary theory to cancer: a long and winding road

Frédéric Thomas, Daniel Fisher, Philippe Fort, +35

Evolutionary Applications

Cancer BiologyTumor BiologyOncologyTumor HeterogeneityRadiation Oncology +14

Circadian rest‐activity rhythm as an objective biomarker of patient‐reported outcomes in patients with advanced cancer

Pasquale F. Innominato, Sandra Komarzynski, Oxana Palesh, +11

Cancer Medicine

A Combined Experimental and Mathematical Approach for Molecular-based Optimization of Irinotecan Circadian Delivery

Annabelle Ballesta, Sandrine Dulong, Chadi Abbara, +4

PLoS Computational Biology

EngineeringCryptochromeCellular PharmacologyOptogeneticsCancer Biology +24

Identification of Circadian Determinants of Cancer Chronotherapy through <i>In Vitro</i> Chronopharmacology and Mathematical Modeling

Sandrine Dulong, Annabelle Ballesta, Alper Okyar, +1

Molecular Cancer Therapeutics

Sex‐dependent least toxic timing of irinotecan combined with chronomodulated chemotherapy for metastatic colorectal cancer: Randomized multicenter EORTC 05011 trial

Pasquale F. Innominato, Annabelle Ballesta, Qi Huang, +8

Cancer Medicine

Multiscale Design of Cell‐Type–Specific Pharmacokinetic/Pharmacodynamic Models for Personalized Medicine: Application to Temozolomide in Brain Tumors

Annabelle Ballesta, Qingyu Zhou, X Zhang, +2

CPT Pharmacometrics & Systems Pharmacology

Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy

Roger J. Hill, Pasquale F. Innominato, Françis Lévi, +1

PLoS Computational Biology

PharmacotherapySystem PharmacologyInfusion PumpPhysiologically-based Pharmacokinetic ModelingSystems Pharmacology +20

A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer

Janina Hesse, Julien Martinelli, Ouda Aboumanify, +2

Computational and Structural Biotechnology Journal

An Efficient Kinetic Model for Assemblies of Amyloid Fibrils and Its Application to Polyglutamine Aggregation

Stéphanie Prigent, Annabelle Ballesta, Frédérique Charles, +5

PLoS ONE

Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling

Alper Okyar, Swati A. Kumar, Elisabeth Filipski, +11

Scientific Reports