U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

Diane Lefaudeux, Bertrand De Meulder, Matthew J. Loza, +217

Journal of Allergy and Clinical Immunology

AsthmaAllergySputum OmicsMulti-omics StudyImmunology +7

IL-17–high asthma with features of a psoriasis immunophenotype

Jörgen Östling, Marleen van Geest, James Schofield, +279

Journal of Allergy and Clinical Immunology

AsthmaAllergyImmunologyIl-17–high AsthmaMedicine +1

Characterization of Aclidinium Bromide, a Novel Inhaled Muscarinic Antagonist, with Long Duration of Action and a Favorable Pharmacological Profile

Amadeu Gavaldà, Montserrat Miralpeix, Israel Ramos, +13

Journal of Pharmacology and Experimental Therapeutics

Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus

Julio Cortijo, Josep Bou, Jörge Beleta, +4

British Journal of Pharmacology

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

Fumiaki Mori, S. Pérez-Torres, Raffaele De, +6

Journal of Chemical Neuroanatomy

Signal TransductionNeuroanatomyNeurotransmitterMolecular BiologyHuman Area Postrema +6

Adenosine Inhibits Macrophage Colony-Stimulating Factor-Dependent Proliferation of Macrophages Through the Induction of p27 <i>kip-1</i> Expression

Jordi Xaus, Annabel F. Valledor, Marina Cardó, +4

The Journal of Immunology

Characterization of human serotonin 1D and 1B receptors using [ 3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist

Teresa Domènech, Jörge Beleta, José Palacios

Naunyn-Schmiedeberg s Archives of Pharmacology

Functional SelectivityMedicineReceptor AntagonistReceptor (Biochemistry)Neuroscience +5

Novel Heterocyclic-Fused Pyridazinones as Potent and Selective Phosphodiesterase IV Inhibitors

Vittorio Dal Piaz, Maria Paola Giovannoni, Carla Castellana, +4

Journal of Medicinal Chemistry

Identification and characterization of serotonin 5-HT4 receptor binding sites in human brain: comparison with other mammalian species

Teresa Domènech, Jörge Beleta, Anair Graciela Lema Fernandez, +4

Molecular Brain Research

NeurophysiologyNeuroanatomyMedicineNeurotransmitterNeuropeptide Receptor +10

Discovery of Novel Quaternary Ammonium Derivatives of (3<i>R</i>)-Quinuclidinol Esters as Potent and Long-Acting Muscarinic Antagonists with Potential for Minimal Systemic Exposure after Inhaled Administration: Identification of (3<i>R</i>)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide (Aclidinium Bromide)

María Prat, Dolors Fernández, María Antonia Buil, +22

Journal of Medicinal Chemistry