Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

Anju Singh, Sreedhar Venkannagari, Kyu Hee Oh, +22

ACS Chemical Biology

Keap1-deficient Nsclc TumorsSmall Molecule InhibitorCancer BiologyTumor BiologyReceptor Tyrosine Kinase +19

Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction

Jordana B. Cohen, Sarah J. Schrauben, Lei Zhao, +15

JACC Heart Failure

Heart FailureCardiovascular DiseaseMedicineCardiologyDiastolic Function

Assay Guidance Manual [Internet]

Sarine Markossian, A Grossman, Kyle R. Brimacombe, +31

Pharmaceutical ResearchDrug TargetBiochemistryHigh Throughput ScreeningMedicine +13

Multiple Plasma Biomarkers for Risk Stratification in Patients With Heart Failure and Preserved Ejection Fraction

Julio A. Chirinos, Alena Orlenko, Lei Zhao, +16

Journal of the American College of Cardiology

Heart FailureCardiovascular DiseaseCardiac CareMultiple Plasma BiomarkersMedicine +5

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

Hilary A. Kenny, Madhu Lal-Nag, Erin A. White, +12

Nature Communications

Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models

Mindy I. Davis, Rajan Pragani, Jennifer T. Fox, +17

Journal of Biological Chemistry

Assay Guidance Manual

G. Sitta Sittampalam, Nathan P. Coussens, Henrike Nelson, +16

DiagnosisAssay Guidance ManualBiostatisticsAnalytical ChemistryLaboratory Method

Multiplexed ion beam imaging (MIBI) for characterization of the tumor microenvironment across tumor types

Jason Ptacek, Darren Locke, Rachel Finck, +8

Laboratory Investigation

EngineeringOncologic ImagingMedical ImagingBiomedical ImagingTumor Types +6

Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1

Mindy I. Davis, Min Shen, Kimberly Straley, +11

Journal of Biological Chemistry

Symptom Onset in Aortic Stenosis

Anvesha Singh, Daniel C. S. Chan, John P. Greenwood, +16

JACC. Cardiovascular imaging

Cardiovascular DiseaseAortic DiseasesAortic StenosisValve DiseaseArterial Disease +3