Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.

Taro Kanaya, Satoru Kyo, Katsuyuki Hamada, +4

PubMed

Wild-type P53Oncogenic AgentNatural SciencesAdenoviral ExpressionApoptosis +13

Restoration of wild-type p16 down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas.

Hironobu Harada, Kou Nakagawa, Shinji Iwata, +5

PubMed

Neuro-oncologyInhibits AngiogenesisP16 Gene ReplacementAngiogenesisGlioma +12

Adenovirus-mediated transfer of a wild-type p53 gene and induction of apoptosis in cervical cancer.

Katsuyuki Hamada, Ramón Alemany, Wei Wei Zhang, +4

PubMed

Gene TherapiesWild-type P53 GeneCervical CancerMedicineAd5cmv-p53 Treatment +13

DNA/polyethyleneimine/hyaluronic acid small complex particles and tumor suppression in mice

Tomoko Ito, Chieko Yoshihara, Katsuyuki Hamada, +1

Biomaterials

NanomedicineEngineeringPolymer-drug ConjugateSmall Complex ParticlesGene Delivery +7

Cytotoxic Effects of Recombinant Adenovirus p53 and Cell Cycle Regulator Genes (p21 sup WAF1/CIP1 and p16 sup CDKN4) in Human Prostate Cancers

Akinobu Gotoh, Chinghai Kao, Song-Chu Ko, +3

The Journal of Urology

Suppression of the immune response to an adenovirus vector and enhancement of intratumoral transgene expression by low-dose etoposide

Michael Bouvet, Bingliang Fang, Sühendan Ekmekçioglu, +5

Gene Therapy

Adenovirus VectorImmunologyGene VectorImmunotherapyMedicine +4

Adenovirus-Mediated Transfer of HPV 16E6/E7Antisense RNA to Human Cervical Cancer Cells

Katsuyuki Hamada, Morito Sakaue, Ramón Alemany, +3

Gynecologic Oncology

Viral ReplicationMolecular VirologyCervical CancerHuman Papillomavirus VaccinesHpv 16E6/e7antisense +8

Mutation and allelic loss of the p53 gene in endometrial carcinoma. Incidence and outcome in 92 surgical patients

Toshimasa Kihana, Katsuyuki Hamada, Yasuhiro Inoue, +5

Cancer

Etodolac, a Selective Cyclooxygenase-2 Inhibitor, Induces Upregulation of E-Cadherin and Has Antitumor Effect on Human Bladder Cancer Cells In Vitro and In Vivo

Asako Okamoto, Toshiro Shirakawa, Toshinori Bito, +5

Urology

Tumor BiologyUrologyOncologyHas Antitumor EffectGenitourinary Cancer +8

Growth Inhibition of Human Cervical Cancer Cells with the Recombinant Adenovirusp53 in Vitro

Katsuyuki Hamada, Weiwei Zhang, Ramón Alemany, +2

Gynecologic Oncology

Recombinant Adenovirusp53Tumor BiologyCancer-associated VirusCervical CancerGrowth Inhibition +7