Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark, +28

Nature Biotechnology

Medicinal ChemistryImmunocytochemical TechniqueDrug TargetingTherapeutic IndexMedicine +8

Blocking Neuropilin-1 Function Has an Additive Effect with Anti-VEGF to Inhibit Tumor Growth

Qi Pan, Yvan H. Chanthery, Wei‐Ching Liang, +17

Cancer Cell

Neuro-oncologyInhibit Tumor GrowthMedicineCancer GrowthCell Biology +9

Kinetic Analysis of Epidermal Growth Factor Receptor Somatic Mutant Proteins Shows Increased Sensitivity to the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, Erlotinib

Kendall D. Carey, Andrew J. Garton, Maria S. Romero, +7

Cancer Research

Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site

Jenny Boström, Shang‐Fan Yu, David Kan, +8

Science

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice

Jing Qing, Xiangnan Du, Yongmei Chen, +16

Journal of Clinical Investigation

Bladder CarcinomaFgf Receptor 3Genitourinary CancerMedicineImmunology +13

An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells

Nicholas S. Wilson, Becky Yang, Annie Yang, +17

Cancer Cell

Antibody-mediated Target-receptor SignalingCancer ImmunosurveillanceSignal TransductionSignaling PathwayMedicine +13

Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection

Andrew G. Polson, Jill Calemine-Fenaux, Pamela Chan, +26

Cancer Research

ImmunologyChemical LinkersImmunotherapeuticsImmunotherapyTumor Biology +15

Imaging Tumors with an Albumin-Binding Fab, a Novel Tumor-Targeting Agent

Mark S. Dennis, Hongkui Jin, Debra L. Dugger, +7

Cancer Research

EngineeringOncologic ImagingMedicineTheranosticsPathology +13

MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival

Renhui Yang, Zhong Zheng, Mally Romero, +7

Cancer Research

ImmunologyPathologyCell ProliferationImmunotherapeuticsCancer Biology +20

Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma

Andrew G. Polson, Shang‐Fan Yu, Kristi Elkins, +18

Blood