The effects of RFRP-3, the mammalian ortholog of GnIH, on the female pig reproductive axis in vitro

Xun� Li, Juan Su, Rui Fang, +9

Molecular and Cellular Endocrinology

Animal PhysiologyAnimal ReproductionDevelopmental BiologyFertilityMammalian Ortholog +11

Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase

Ruipeng Lei, Wooseob Kim, Huibin Lv, +18

Immunity

VaccinationCross-protectionInfluenza N2 NeuraminidaseVaccine DevelopmentVaccine Target +7

Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing

Yiquan Wang, Ruipeng Lei, Armita Nourmohammad, +1

eLife

EngineeringImmunologyMolecular BiologyCharge BalancingViral Structural Protein +15

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike

Timothy J.C. Tan, Zongjun Mou, Ruipeng Lei, +9

Nature Communications

VaccinationViral EvolutionEngineeringVaccine DevelopmentVaccine Target +13

An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies

Yiquan Wang, Huibin Lv, Qi Wen Teo, +10

Immunity

VaccinationNatural Language ProcessingExplainable Language ModelCorpus LinguisticsAntibody Specificity Prediction +8

Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning

Wenhao O. Ouyang, Timothy J.C. Tan, Ruipeng Lei, +5

Science Advances

ImmunologyMolecular BiologyNtd Single MutationsViral Structural ProteinImmunotherapy +16

Inhibition of base excision repair by natamycin suppresses prostate cancer cell proliferation

Judy L. Vasquez, Yanhao Lai, Thirunavukkarasu Annamalai, +7

Biochimie

UrologyCancer Cell ProliferationMedicineNatamycin SuppressesTumor Suppressor +4

Fluorescent 5-Pyrimidine and 8-Purine Nucleosides Modified with an <i>N</i>-Unsubstituted 1,2,3-Triazol-4-yl Moiety

Zhiwei Wen, Paloma R. Tuttle, A. Hasan Howlader, +8

The Journal of Organic Chemistry

Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin

Ruipeng Lei, Weiwen Liang, Wenhao O. Ouyang, +16

Nature Communications

Mutational fitness landscape of human influenza H3N2 neuraminidase

Ruipeng Lei, Andrea Hernandez Garcia, Timothy J.C. Tan, +7

Cell Reports

VaccinationViral EvolutionEngineeringPathogenesisComputational Biology +12