Howard K. Plummer

The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid.

Hildegard M. Schuller, Patricia K. Tithof, Monique Williams et al. · PubMed · 1999 · 189 citations

Medicine, Oncology, Pharmacology +14

Interaction of tobacco-specific toxicants with the neuronal α7 nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders

Hildegard M. Schuller, Brian A. Jull, Barbara J. Sheppard et al. · European Journal of Pharmacology · 2000 · 109 citations

Pharmacy, Pharmacology, Toxicology +16

Expression of the α7 nicotinic acetylcholine receptor in human lung cells

Howard K. Plummer, Madhu Dhar, Hildegard M. Schuller · Respiratory Research · 2005 · 93 citations · Full text

Medicine, Molecular Biology, Pharmacology +13

Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention

Hildegard M. Schuller, Hussein A.N. Al-Wadei, Mohammad Fahad Ullah et al. · Carcinogenesis · 2011 · 88 citations · Full text

Life Sciences, Neuroscience, Oncology +17

Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter  -aminobutyric acid

Hussein A.N. Al-Wadei, Howard K. Plummer, Hildegard M. Schuller · Carcinogenesis · 2009 · 71 citations · Full text

Medicine, Oncology, Pharmacology +17