Frataxin Acts as an Iron Chaperone Protein to Modulate Mitochondrial Aconitase Activity

Anne-Laure Bulteau, Heather A. O’Neill, M C Kennedy, +3

Science

Reductive StressRedox SignalingBiochemistryMitochondrial FunctionMedicine +11

Iron-Dependent Self-Assembly of Recombinant Yeast Frataxin: Implications for Friedreich Ataxia

Jiří Adamec, Frank Rusnak, Whyte G. Owen, +4

The American Journal of Human Genetics

BiochemistryProtein FoldingNatural SciencesMolecular BiologyYeast +4

Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity

Oleksandr Gakh, Sungjo Park, Gang Liu, +4

Human Molecular Genetics

Reductive StressMitochondrial BiogenesisMitochondrial FunctionBiochemistryLongevity +13

Yeast Frataxin Sequentially Chaperones and Stores Iron by Coupling Protein Assembly with Iron Oxidation

Sungjo Park, Oleksandr Gakh, Heather A. O’Neill, +4

Journal of Biological Chemistry

Cleavage of precursors by the mitochondrial processing peptidase requires a compatible mature protein or an intermediate octapeptide.

Grazia Isaya, František Kalousek, Wayne A. Fenton, +1

The Journal of Cell Biology

Molecular BiologyCompatible Mature ProteinProtein SynthesisPurified MppBiosynthesis +15

Reversible redox-dependent modulation of mitochondrial aconitase and proteolytic activity during <i>in vivo</i> cardiac ischemia/reperfusion

Anne-Laure Bulteau, Kathleen C. Lundberg, Masao Ikeda‐Saito, +2

Proceedings of the National Academy of Sciences

Cardiac Ischemia/reperfusionMitochondrial BiologyRedox BiologyOxidative StressMitochondrial Aconitase +14

Physical Evidence that Yeast Frataxin Is an Iron Storage Protein

Oleksandr Gakh, Jiří Adamec, A. Marquis Gacy, +3

Biochemistry

Protein ChemistryProtein SubunitsBiochemistryProtein AssemblyProtein Folding +12

Cryptic proteolytic activity of dihydrolipoamide dehydrogenase

Ngolela Esther Babady, Yuan‐Ping Pang, Orly Elpeleg, +1

Proceedings of the National Academy of Sciences

Prediction and Identification of New Natural Substrates of the Yeast Mitochondrial Intermediate Peptidase

Steven S. Branda, Grazia Isaya

Journal of Biological Chemistry

Two-step Processing of Human Frataxin by Mitochondrial Processing Peptidase

Patrizia Cavadini, Jiří Adamec, Franco Taroni, +2

Journal of Biological Chemistry