Grazia Isaya

Frataxin Acts as an Iron Chaperone Protein to Modulate Mitochondrial Aconitase Activity

Anne-Laure Bulteau, Heather A. O’Neill, M C Kennedy et al. · Science · 2004 · 368 citations

Reductive Stress, Redox Signaling, Biochemistry +13

Iron-Dependent Self-Assembly of Recombinant Yeast Frataxin: Implications for Friedreich Ataxia

Jiří Adamec, Frank Rusnak, Whyte G. Owen et al. · The American Journal of Human Genetics · 2000 · 249 citations · Full text

Biochemistry, Protein Folding, Natural Sciences +6

Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity

Oleksandr Gakh, Sungjo Park, Gang Liu et al. · Human Molecular Genetics · 2005 · 182 citations · Full text

Reductive Stress, Mitochondrial Biogenesis, Mitochondrial Function +15

Yeast Frataxin Sequentially Chaperones and Stores Iron by Coupling Protein Assembly with Iron Oxidation

Sungjo Park, Oleksandr Gakh, Heather A. O’Neill et al. · Journal of Biological Chemistry · 2003 · 162 citations · Full text

Cleavage of precursors by the mitochondrial processing peptidase requires a compatible mature protein or an intermediate octapeptide.

Grazia Isaya, František Kalousek, Wayne A. Fenton et al. · The Journal of Cell Biology · 1991 · 132 citations · Full text

Molecular Biology, Compatible Mature Protein, Protein Synthesis +17