Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

Bernd K. Gilsbach, Franz Y. Ho, Ingrid R. Vetter, +3

Proceedings of the National Academy of Sciences

Signal RecognitionMolecular BiologyRoco Kinase StructuresSignaling PathwayReceptor Tyrosine Kinase +14

Allosteric Inhibition of Parkinson’s-Linked LRRK2 by Constrained Peptides

Leah G. Helton, Ahmed Soliman, Felix von Zweydorf, +15

ACS Chemical Biology

Molecular PharmacologySignal TransductionConstrained PeptidesSignaling PathwayG Protein-coupled Receptor +12

The critical role of caspases activation in hypoxia/reoxygenation induced apoptosis

Franz Y. Ho, W.P. Tsang, Siu Kai Kong, +1

Biochemical and Biophysical Research Communications

InflammationSignal TransductionBiochemistryRedox RegulatorApoptosis +10

Revisiting the Roco G-protein cycle

Susanne Terheyden, Franz Y. Ho, Bernd K. Gilsbach, +2

Biochemical Journal

p53‐R175H mutant gains new function in regulation of doxorubicin‐induced apoptosis

Wing‐pui Tsang, Franz Y. Ho, Kwok‐Pui Fung, +2

International Journal of Cancer

Evolved Escherichia coli Strains for Amplified, Functional Expression of Membrane Proteins

Nadia Gul, Daniel M. Linares, Franz Y. Ho, +1

Journal of Molecular Biology

Functional ExpressionBacteriologyMolecular BiologyEscherichia Coli StrainsMicrobiology +2

Conformational heterogeneity of the Roc domains in <i>C. tepidum</i> Roc–COR and implications for human LRRK2 Parkinson mutations

Katharina Rudi, Franz Y. Ho, Bernd K. Gilsbach, +4

Bioscience Reports

Protein AssemblyStructural BioinformaticsBiomolecular Structure PredictionMolecular BiologyG-protein Cycle +14

The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation

Susanna Cogo, Franz Y. Ho, Elena Tosoni, +14

Brain Research

Protein FunctionSignal TransductionProtein-protein InteractionsBiochemistrySignaling Pathway +12

Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization

Pragya Pathak, Krista K. Alexander, Leah G. Helton, +11

ACS Chemical Neuroscience

Biophysical analysis reveals autophosphorylation as an important negative regulator of LRRK2 dimerization

Giambattista Guaitoli, Xiaojuan Zhang, Francesca Saitta, +9