Gerry McLachlan

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial

Eric W.F.W. Alton, David K Armstrong, Deborah Ashby et al. · The Lancet Respiratory Medicine · 2015 · 424 citations · Full text

Pharmacy, Molecular Medicine, Pharmacotherapy +17

Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

Eric W.F.W. Alton, Peter G. Middleton, Natasha J. Caplen et al. · Nature Genetics · 1993 · 400 citations

Pharmacy, Genetics, Molecular Biology +17

Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis

JR Dorin, Gerry McLachlan, Hazel Davidson‐Smith et al. · Gene Therapy · 1997 · 324 citations

Pharmacy, Molecular Biology, Molecular Pharmaceutics +15

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis

Eric W.F.W. Alton, Jeffrey M. Beekman, A. Christopher Boyd et al. · Thorax · 2016 · 146 citations · Full text

Pharmacy, Molecular Pharmaceutics, Translational Sciences +13

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung

Gerry McLachlan, H Davidson, Emma Holder et al. · Gene Therapy · 2011 · 103 citations

Pharmacy, Molecular Medicine, Pharmaceutics +17