Jotaro Igarashi

Elucidation of the Heme Binding Site of Heme-regulated Eukaryotic Initiation Factor 2α Kinase and the Role of the Regulatory Motif in Heme Sensing by Spectroscopic and Catalytic Studies of Mutant Proteins

Jotaro Igarashi, Motohiko Murase, Aya Iizuka et al. · Journal of Biological Chemistry · 2008 · 101 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Minimal Pharmacophoric Elements and Fragment Hopping, an Approach Directed at Molecular Diversity and Isozyme Selectivity. Design of Selective Neuronal Nitric Oxide Synthase Inhibitors

Haitao Ji, Benjamin Z. Stanton, Jotaro Igarashi et al. · Journal of the American Chemical Society · 2008 · 99 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Important Roles of Tyr43 at the Putative Heme Distal Side in the Oxygen Recognition and Stability of the Fe(II)−O₂ Complex of YddV, a Globin-Coupled Heme-Based Oxygen Sensor Diguanylate Cyclase

Kenichi Kitanishi, Kazuo Kobayashi, Yuriko Kawamura et al. · Biochemistry · 2010 · 78 citations

Life Sciences, Biochemistry, Molecular Biology +17

Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy

Haitao Ji, Sidhartha Tan, Jotaro Igarashi et al. · Annals of Neurology · 2009 · 77 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Activation of Heme-regulated Eukaryotic Initiation Factor 2α Kinase by Nitric Oxide Is Induced by the Formation of a Five-coordinate NO-Heme Complex

Jotaro Igarashi, Akira Sato, Teizo Kitagawa et al. · Journal of Biological Chemistry · 2004 · 72 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13