Jeff Settleman

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella et al. · New England Journal of Medicine · 2004 · 11.4K citations

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

Sreenath V. Sharma, Diana Lee, Bihua Li et al. · Cell · 2010 · 2.7K citations · Full text

Chromatin, Chromatin Remodeling, Medicine +6

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

Timothy R. Wilson, Jane Fridlyand, Yibing Yan et al. · Nature · 2012 · 1.1K citations · Full text

Medicine, Kinase Inhibitors, Anti-cancer Agent +6

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

Anurag Singh, Patricia Greninger, Daniel R. Rhodes et al. · Cancer Cell · 2009 · 855 citations · Full text

Tumor Biology, Transcriptional Regulation, Signal Transduction +11

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

Rushika M. Perera, Svetlana Stoykova, Brandon Nicolay et al. · Nature · 2015 · 778 citations · Full text

Cell Autophagy, Pancreatic Cancer, Medicine +7