The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

Yun Xia, Yonghua Xie, Zhengsen Yu, +20

Cell

VaccinationDruggable TargetVaccine DevelopmentVaccine ResearchVaccine Target +9

Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection

Xiaohui Wang, Xiang Lin, Zihan Zheng, +21

Nature Communications

Ultrahigh frequencies of peripherally matured LGI1- and CASPR2-reactive B cells characterize the cerebrospinal fluid in autoimmune encephalitis

Jakob Theorell, Ruby Harrison, Robyn Williams, +16

Proceedings of the National Academy of Sciences

Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors

Jingjing Liang, Jun Lyu, Meng Zhao, +10

Nature Communications

Metabolomic Analysis and Identification of Sperm Freezability-Related Metabolites in Boar Seminal Plasma

Yuting Zhang, Hanlin Liang, Yan Liu, +3

Animals

FertilityBoar Sperm FreezabilitySperm FreezabilitySemen AnalysisReproductive Biology +19

Fc receptor–like 1 intrinsically recruits c-Abl to enhance B cell activation and function

Xingwang Zhao, Hengyi Xie, Meng Zhao, +10

Science Advances

Ion channel TRPV2 is critical in enhancing B cell activation and function

Cuifeng Li, Meng Zhao, Xiaohang Liu, +17

The Journal of Experimental Medicine

Humoral ResponseImmunologyB Cell ActivationImmunodominanceTrpv2 Expression +20

The Heptahelical Domain of the Sweet Taste Receptor T1R2 Is a New Allosteric Binding Site for the Sweet Taste Modulator Amiloride That Modulates Sweet Taste in a Species-Dependent Manner

Meng Zhao, Xiangqun Xu, Xuan-Yu Meng, +1

Journal of Molecular Neuroscience

BiochemistryFunctional SelectivityMedicineReceptor (Biochemistry)Heptahelical Domain +4

Sex-Specific Effects of Polystyrene Microplastic and Lead(II) Co-Exposure on the Gut Microbiome and Fecal Metabolome in C57BL/6 Mice

Weishou Shen, Meng Zhao, Weichen Xu, +6

Metabolites

Strikingly Reduced Amyloid Burden and Improved Behavioral Performance in Alzheimer's Disease Mice Immunized with Recombinant Chimeric Vaccines by Hexavalent Foldable Aβ1-15 Fused to Toxin-Derived Carrier Proteins

Yun‐Zhou Yu, Wenbin Wang, Ao Chen, +8

Journal of Alzheimer s Disease

Adaptive Immune SystemImmunologyImmune RegulationImmunodominanceCd4 T Cell Responses +26