Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

Kayode K. Ojo, E.T. Larson, Katelyn R. Keyloun, +15

Nature Structural & Molecular Biology

Selective Kinase InhibitorsSignal TransductionSignaling PathwayReceptor Tyrosine KinasePathology +4

Discovery of Potent and Selective Inhibitors of CDPK1 from <i>C. parvum</i> and <i>T. gondii</i>

Ryan C. Murphy, Kayode K. Ojo, E.T. Larson, +11

ACS Medicinal Chemistry Letters

Pharmaceutical ScienceDrug TargetImmunologyPathologySelective Inhibitors +20

Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection

Cho Yeow Koh, Jessica E. Kim, S. Shibata, +8

Structure

BiochemistryProtein FoldingMedicineNatural SciencesRna Structure Prediction +8

Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1

E.T. Larson, Kayode K. Ojo, Ryan C. Murphy, +16

Journal of Medicinal Chemistry

Bioorganic ChemistryMolecular BiologyCryptosporidium ParvumChemical BiologyCellular Physiology +18

Urea-Based Inhibitors of Trypanosoma brucei Methionyl-tRNA Synthetase: Selectivity and in Vivo Characterization

S. Shibata, J. Robert Gillespie, Ranae M. Ranade, +8

Journal of Medicinal Chemistry

Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate

E.T. Larson, Jessica E. Kim, Frank Zucker, +9

Biochimie

BiosynthesisCellular EnzymologyBiochemistryNatural SciencesBiocatalysis +7

The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer

E.T. Larson, Jessica E. Kim, Lisa J. Castaneda, +9

Journal of Molecular Biology

BiochemistryParasitic ProtozoaNatural SciencesProtein BiosynthesisDouble-length Tyrosyl-trna Synthetase +7

Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness

Cho Yeow Koh, Jessica E. Kim, A.B. Wetzel, +10

PLoS neglected tropical diseases

Crystal StructureDrug TargetMethionyl-trna SynthetaseMolecular BiologySleeping Sickness +15

Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design

Cho Yeow Koh, Jessica E. Kim, Alberto J. Napoli, +5

Molecular and Biochemical Parasitology

BiochemistryCytosolic Tryptophanyl-trna SynthetaseNatural SciencesBiomolecular Structure PredictionRational Drug Design +7

Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase

E.A. Merritt, T.L. Arakaki, Robert A. Gillespie, +8

Molecular and Biochemical Parasitology

Crystal StructuresProtein X-ray CrystallographyStructural BiologyBiochemistry