Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation

Kun Bi, Yoshihiko Tanaka, Nolwenn Coudronnière, +4

Nature Immunology

Antigen-induced TranslocationT Cell ActivationSignal TransductionCell SignalingCell Trafficking +11

Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis

Akihiko Nishikimi, Hideo Fukuhara, Wenjuan Su, +13

Science

Proteinlipid InteractionCytoskeletonLipid MovementNeutrophil ChemotaxisCellular Physiology +18

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

Yosuke Harada, Yoshihiko Tanaka, Masao Terasawa, +15

Blood

Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells

Martín Villalba, Kun Bi, Fernando Rodrı́guez, +3

The Journal of Cell Biology

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

Yuya Kunisaki, Akihiko Nishikimi, Yoshihiko Tanaka, +8

The Journal of Cell Biology

Molecular BiologyRac ActivatorCytoskeletonInnate ImmunityNeutrophil Chemotaxis +14

Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse

Audrey Le Floc’h, Yoshihiko Tanaka, Niels S. Bantilan, +4

The Journal of Experimental Medicine

Gtpase RasImmunologyCell DeathCytoskeletonSynaptic Signaling +18

Impaired Activation and Localization of LAT in Anergic T Cells as a Consequence of a Selective Palmitoylation Defect

Matthias Hundt, Hiroki Tabata, Myung‐Shin Jeon, +7

Immunity

Signal TransductionSelective Palmitoylation DefectT-regulatory CellImpaired ActivationMolecular Biology +6

Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation

Kazuhito Gotoh, Yoshihiko Tanaka, Akihiko Nishikimi, +14

The Journal of Experimental Medicine

Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator DOCK2

Akihiko Nishikimi, Takehito Uruno, Xuefeng Duan, +20

Chemistry & Biology

InflammationInflammatory ResponsesAnti-inflammatoryRac Activator Dock2Medicine +10

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction

Kazuhiko Yamamura, Takehito Uruno, Akira Shiraishi, +8

Nature Communications