Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells.

Daniel J. Price, Tihomir Miralem, Shuxian Jiang, +2

PubMed

Breast OncologyImmunologyVegf SecretionTumor BiologyAngiogenesis +16

Biliverdin Reductase, a Novel Regulator for Induction of Activating Transcription Factor-2 and Heme Oxygenase-1

Anatoliy Kravets, Zhenbo Hu, Tihomir Miralem, +2

Journal of Biological Chemistry

Molecular RegulationHbvr AntibodyImmunologyHeme Oxygenase-1Hbvr Modulation +19

Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling

Nicole Lerner‐Marmarosh, Tihomir Miralem, Peter Gibbs, +1

Proceedings of the National Academy of Sciences

Systems BiologySignal TransductionHuman Biliverdin ReductaseHbvr ActivationSignaling Pathway +13

Small Interference RNA-mediated Gene Silencing of Human Biliverdin Reductase, but Not That of Heme Oxygenase-1, Attenuates Arsenite-mediated Induction of the Oxygenase and Increases Apoptosis in 293A Kidney Cells

Tihomir Miralem, Zhenbo Hu, Michael D. Torno, +2

Journal of Biological Chemistry

VEGF165 requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells

Tihomir Miralem, Robert A. Steinberg, Dan R.G. Price, +1

Oncogene

Migratory ResponseMitogenic EffectsMedicineCell-matrix InteractionCell Proliferation +11

Heparin Inhibits Mitogen-activated Protein Kinase-dependent and -independent c- Induction in Mesangial Cells

Tihomir Miralem, Aimin Wang, Catharine Whiteside, +1

Journal of Biological Chemistry

Regulation of TNF‐α‐activated PKC‐ζ signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase

Nicole Lerner‐Marmarosh, Tihomir Miralem, Peter Gibbs, +1

The FASEB Journal

Molecular RegulationMolecular BiologyTnf‐α‐activated Pkc‐ζHuman Biliverdin ReductaseSignaling Pathway +17

Human Biliverdin Reductase, a Previously Unknown Activator of Protein Kinase C βII

Mahin D. Maines, Tihomir Miralem, Nicole Lerner‐Marmarosh, +2

Journal of Biological Chemistry

Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol‐dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation

Tihomir Miralem, Nicole Lerner‐Marmarosh, Peter Gibbs, +3

The FASEB Journal

Formation of Ternary Complex of Human Biliverdin Reductase-Protein Kinase Cδ-ERK2 Protein Is Essential for ERK2-mediated Activation of Elk1 Protein, Nuclear Factor-κB, and Inducible Nitric-oxidase Synthase (iNOS)

Peter Gibbs, Tihomir Miralem, Nicole Lerner‐Marmarosh, +2

Journal of Biological Chemistry

Redox SignalingTranscriptional RegulationProtein Quality ControlSignal TransductionBiochemistry +11