Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: results from three phase 3, multicentre, double-blind, randomised trials

Silvio Danese, Séverine Vermeire, Wen Zhou, +20

The Lancet

Anti-inflammatorySystemic TreatmentGastroenterologyClinical TrialsMaintenance Therapy +5

Efficacy of Upadacitinib in a Randomized Trial of Patients With Active Ulcerative Colitis

William J. Sandborn, Subrata Ghosh, Julián Panés, +9

Gastroenterology

Production of human monoclonal antibody in eggs of chimeric chickens

Lei Zhu, Marie‐Cecile van de Lavoir, Jenny Albanese, +26

Nature Biotechnology

AllergyPoultry DiseaseHuman Monoclonal AntibodyImmunologyPoultry Farming +4

Single-cell transcriptomic landscape of human blood cells

Xiaowei Xie, Mengyao Liu, Yawen Zhang, +26

National Science Review

Lymphocyte DevelopmentSingle-cell Rna-seqImmunologyBlood CellHuman Blood Cells +21

Lycorine Downregulates HMGB1 to Inhibit Autophagy and Enhances Bortezomib Activity in Multiple Myeloma

Mridul Roy, Long Liang, Xiaojuan Xiao, +10

Theranostics

Epigenetic silencing of miR-137 induces drug resistance and chromosomal instability by targeting AURKA in multiple myeloma

Yu Qin, Simin Zhang, Shuhui Deng, +9

Leukemia

Epigenetic SilencingHematological MalignancyChromosomal InstabilityCancer GenomicsMultiple Myeloma +8

MSX2 Initiates and Accelerates Mesenchymal Stem/Stromal Cell Specification of hPSCs by Regulating TWIST1 and PRAME

Leisheng Zhang, Hongtao Wang, Cuicui Liu, +8

Stem Cell Reports

Regenerative MedicineDevelopmental BiologyMedicineHpsc DifferentiationMsx2 Initiates +9

Lipofectamine RNAiMAX: An Efficient siRNA Transfection Reagent in Human Embryonic Stem Cells

Ming Zhao, Hong Yang, Xingjun Jiang, +5

Molecular Biotechnology

Regenerative MedicineLipofectamine RnaimaxInduced Pluripotent Stem CellDevelopmental BiologyMedicine +5

Upadacitinib Therapy Reduces Ulcerative Colitis Symptoms as Early as Day 1 of Induction Treatment

Edward V. Loftus, Jean‐Frédéric Colombel, Ken Takeuchi, +14

Clinical Gastroenterology and Hepatology

InflammationAnti-inflammatoryDay 1GastroenterologyInduction Treatment +3

Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance

Jiliang Xia, Jingyu Zhang, Xuan Wu, +19

Nature Communications