Andrew J. Kale

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from <i>S</i> -adenosyl- <scp>l</scp> -methionine

Alessandra S. Eustáquio, Ryan P. McGlinchey, Yuan Liu et al. · Proceedings of the National Academy of Sciences · 2009 · 179 citations · Full text

Polyketide Scaffolds, Halogenation, Biosynthesis +14

The Carmaphycins: New Proteasome Inhibitors Exhibiting an α,β‐Epoxyketone Warhead from a Marine Cyanobacterium

Albán R. Pereira, Andrew J. Kale, Andrew T. Fenley et al. · ChemBioChem · 2012 · 119 citations · Full text

Molecular Mechanisms of Acquired Proteasome Inhibitor Resistance

Andrew J. Kale, Bradley S. Moore · Journal of Medicinal Chemistry · 2012 · 92 citations · Full text

Proteasome Inhibitors, Drug Resistance Analysis, Protein Function +15

Function-Oriented Biosynthesis of β-Lactone Proteasome Inhibitors in <i>Salinispora tropica</i>

Markus Nett, Tobias A. M. Gulder, Andrew J. Kale et al. · Journal of Medicinal Chemistry · 2009 · 68 citations · Full text

Salinosporamide Analogues, Chemical Biology, Enzymatic Modification +16

Bacterial Self-Resistance to the Natural Proteasome Inhibitor Salinosporamide A

Andrew J. Kale, Ryan P. McGlinchey, Anna Lechner et al. · ACS Chemical Biology · 2011 · 53 citations

Proteasome Inhibitors, Molecular Biology, Antibiotic Resistance +17