Paul A. Sigala

The Heme Biosynthesis Pathway Is Essential for Plasmodium falciparum Development in Mosquito Stage but Not in Blood Stages

Hangjun Ke, Paul A. Sigala, Kazutoyo Miura et al. · Journal of Biological Chemistry · 2014 · 178 citations · Full text

Biology, Biosynthesis, Heme Biosynthesis Pathway +11

Decomposition of Vibrational Shifts of Nitriles into Electrostatic and Hydrogen-Bonding Effects

Aaron T. Fafarman, Paul A. Sigala, Daniel Herschlag et al. · Journal of the American Chemical Society · 2010 · 162 citations · Full text

Testing Electrostatic Complementarity in Enzyme Catalysis: Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole

Daniel A. Kraut, Paul A. Sigala, Brandon Pybus et al. · PLoS Biology · 2006 · 143 citations · Full text

Bioorganic Chemistry, Biochemistry, Natural Sciences +13

Deconvoluting heme biosynthesis to target blood-stage malaria parasites

Paul A. Sigala, Jan R. Crowley, Jeffrey P. Henderson et al. · eLife · 2015 · 110 citations · Full text

Biosynthesis, Biochemistry, Photochemistry +15

Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase

Aaron T. Fafarman, Paul A. Sigala, Jason P. Schwans et al. · Proceedings of the National Academy of Sciences · 2012 · 103 citations · Full text