Concepedia

Zoltán Orgován

ZO

Statistics

Publications

5

Citations

194

H-Index

5

Active since

2017

Affiliations

HUN-REN Research Centre for Natural Sciences(Current)

Zoltán Orgován is an author at HUN-REN Research Centre for Natural Sciences specializing in drug discovery, medicinal chemistry, and psychopharmacology.

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Publications per year

2017–2023

5

Publications

5

Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu <sub>5</sub> ) X-ray Structures

J.A. Christopher, Zoltán Orgován, Miles Congreve et al. · Journal of Medicinal Chemistry · 2018 · 91 citations

Structural impact of GTP binding on downstream KRAS signaling

Dóra K. Menyhárd, Gyula Pálfy, Zoltán Orgován et al. · Chemical Science · 2020 · 49 citations · Full text

Discovery and Preclinical Characterization of 3-((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications

János Galambos, Attila Bielik, Mikhail Krasavin et al. · Journal of Medicinal Chemistry · 2017 · 29 citations · Full text

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The role of water and protein flexibility in the structure-based virtual screening of allosteric GPCR modulators: an mGlu5 receptor case study

Zoltán Orgován, György G. Ferenczy, György M. Keserű · Journal of Computer-Aided Molecular Design · 2019 · 13 citations · Full text

Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors

Aaron Keeley, Aleksandra Kopranovic, V. di Lorenzo et al. · Journal of Medicinal Chemistry · 2023 · 12 citations · Full text

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