Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, +37

Cancer Discovery

Digestion and depletion of abundant proteins improves proteomic coverage

Bryan R. Fonslow, Benjamin D. Stein, Kristofor J. Webb, +4

Nature Methods

Proteomic TechnologyNatural SciencesProteasomeMolecular BiologyAbundant Proteins +1

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

Yuxiang Zheng, Ting-Yu Lin, Gina Lee, +10

Cell

BiochemistryMitochondrial FunctionMedicineCancer CellsCancer Biology +3

Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice

Daniel B. McClatchy, Yuanhui Ma, Chao Liu, +6

Journal of Proteome Research

Proteomic TechnologyProtein ExpressionSignaling PathwayHepatotoxicityBiomarker Discovery +16

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

Eric E. Gardner, Ethan M. Earlie, Kate Li, +7

Science

Basal Stem CellLineage PlasticitySomatic VariantTumor MicroenvironmentGenetic Disorder +12

1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia

Petr Váchal, Shouwu Miao, Joan M. Pierce, +28

Journal of Medicinal Chemistry

Pharmaceutical ScienceDrug TargetEfficacious Pan-inhibitorsPharmacotherapyChemical Biology +19

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

Benjamin D. Stein, Diego Calzolari, Kristina Hellberg, +9

Cell Reports

LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma

Benjamin D. Stein, John R. Ferrarone, Eric E. Gardner, +16

Cancer Discovery

Application of Affinity Selection/Mass Spectrometry to Determine the Structural Isomer of Parnafungins Responsible for Binding Polyadenosine Polymerase

Gregory C. Adam, Craig A. Parish, Douglas Wisniewski, +9

Journal of the American Chemical Society

Bioorganic ChemistryMolecular BiologyMedicinal FungiBinding Polyadenosine PolymeraseEnzymatic Modification +17

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

Eric E. Gardner, Ethan M. Earlie, Kate Li, +7