Helen Carrasco Hope

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function

Matteo Morotti, Alizée J Grimm, Helen Carrasco Hope et al. · Nature · 2024 · 163 citations · Full text

Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation

Helen Carrasco Hope, Rebecca J. Brownlie, Christopher M. Fife et al. · JCI Insight · 2021 · 55 citations · Full text

T-regulatory Cell, Immunology, Immunologic Mechanism +20

Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems

Mukul Girotra, Yi-Hsuan Chiang, Mélanie Charmoy et al. · Nature Aging · 2023 · 55 citations · Full text

Aging, Mitochondrial Function, Immune Systems +11

Age-associated nicotinamide adenine dinucleotide decline drives CAR-T cell failure

Helen Carrasco Hope, Jana de Sostoa, Pierpaolo Ginefra et al. · Nature Cancer · 2025 · 16 citations · Full text

Urolithin-A Promotes CD8+ T Cell–mediated Cancer Immunosurveillance via FOXO1 Activation

Pierpaolo Ginefra, Helen Carrasco Hope, Yi-Hsuan Chiang et al. · Cancer Research Communications · 2024 · 13 citations · Full text